Cardiac Ketone Body Oxidation Enhances Exercise Performance

Kara R Gouwens, Ernesto Pena Calderin, Jada Okhiria, Daniel C Nguyen, Emily B Schulman-Geltzer, Yania Martinez-Ondaro, Maleesha De Silva, Helen E Collins, Yibing Nong, Sophia M Sears, Matthew A Nystoriak, Bradford G. Hill

Circulation Research, 2025

Exercise Sensitizes the Pressure Diuresis Response: Shifting Immune Landscapes May Underlie Renal Adaptations to Exercise.

Steven P Jones, Nathan J O'Leary, Ernesto Pena Calderin, Richa A Singhal, Jason Hellmann, Celio Damacena de Angelis, Kenneth R. Brittian, Paul A. Welling, Yibing Nong, Sophia M Sears

AJP - Renal Physiology, 2025

Modeling Cardiorenal Syndrome Type 1: A Time Course Evaluation of Myocardial Infarction-Induced Kidney Injury

Sophia M Sears, Richa A Singhal, Mamata Chaudhari, Daniel C. Nguyen, Kenneth R. Brittian, Bradford G. Hill, Yibing Nong, Steven P. Jones

Journal of Molecular and Cellular Cardiology Plus, 2025

Exercise Increases Resident Macrophage Abundance and Lipoxin A4 in Kidneys

Sophia M. Sears, Ernesto Pena Calderin, Haley Asplund, Richa Singhal, Jason Hellmann, Brian E Sansbury, Steven P Jones

Journal of the American Society of Nephrology, 2024

F4/80hi Resident Macrophages Contribute to Cisplatin-Induced Renal Fibrosis

Sophia M. Sears, Alexis A. Vega, Zimple Kurlawala, Gabrielle B. Oropilla, A. Krueger, P. Shah, M. Doll, Robert Miller, L. Beverly, Leah J. Siskind

Kidney360, 2022

Modeling Cisplatin-Induced Kidney Injury to Increase Translational Potential

Sophia M. Sears, Andrew Orwick, Leah J. Siskind

Nephron, 2022

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury

Sophia M. Sears, T. Dupre, P. Shah, Deanna Davis, M. Doll, Cierra N. Sharp, Alexis A. Vega, J. Megyesi, L. Beverly, A. Snider, L. Obeid, Y. Hannun, Leah J. Siskind

Journal of Lipid Research, 2022

Pharmacologic inhibitors of autophagy have opposite effects in acute and chronic cisplatin-induced kidney injury.

Sophia M. Sears, J. Feng, Andrew Orwick, Alexis A. Vega, A. Krueger, P. Shah, M. Doll, L. Beverly, Leah J. Siskind

AJP - Renal Physiology, 2022

Potential Therapeutic Targets for Cisplatin-Induced Kidney Injury: Lessons from Other Models of AKI and Fibrosis.

Sophia M. Sears, Leah J. Siskind

Journal of the American Society of Nephrology, 2021

C57BL/6 mice require a higher dose of cisplatin to induce renal fibrosis and CCL2 correlates with cisplatin-induced kidney injury.

Sophia M. Sears, Cierra N. Sharp, A. Krueger, Gabrielle B. Oropilla, Douglas Saforo, M. Doll, J. Megyesi, L. Beverly, Leah J. Siskind

AJP - Renal Physiology, 2020